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Image Search Results
Journal: Physiology & behavior
Article Title: Individual differences in the locus coeruleus-norepinephrine system: relevance to stress-induced cardiovascular vulnerability
doi: 10.1016/j.physbeh.2016.07.008
Figure Lengend Snippet: Effect of LC-NE lesion on IL-1β induced pressor response. Rats were implanted with cardiovascular transmitters (HD-S11, Data Sciences Intl.) and an intracerebroventricular (icv) cannula and injected with N-[2-chloroethyl]-N-ethyl-2-bromobenzylamine hydrochloride (400 ug/rat/4min, icv, DSP-4; R & D Systems) or vehicle 30 mins after citalopram hydrobromide (10mg/kg, IP; AK Scientific). One-week later rats were injected with IL-1β (5ng, icv) and the change in mean arterial pressure (MAP, mmHg) from the pre-IL-1β injection baseline was quantified. Rats with a DSP-4 induced LC-NE lesion lacked the IL-1β-induced pressor response. 2-way ANOVA significant interaction: F(2,4)=7.9; p=0.04; Bonferroni post-hoc *p<0.05 vs. DSP-4 treated rat at 90 mins post injection.
Article Snippet: Rats were implanted with cardiovascular transmitters (HD-S11, Data Sciences Intl.) and an intracerebroventricular (icv) cannula and injected with
Techniques: Injection